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Image Search Results
Journal: The Journal of Physiology
Article Title: Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABA A receptors
doi: 10.1113/jphysiol.2009.182444
Figure Lengend Snippet: The curves were generated from the state function for the linear/branched receptor model. The transition constants in the model were determined from the single channel rate constants following the predictive fitting of the single channel data with the linear/branched receptor model using QuB. The data points represent the peaks of simulated currents that were subsequently generated in ChanneLab using the linear/branched model and the best fit single channel rate constants for each agonist. Simulated concentration–response curves for GABA (squares), muscimol (triangles) and THIP (circles) are shown for α1β3γ2 (A), α4β3γ2 (B) and α4β3δ (C) GABAA receptors.
Article Snippet: Simulated whole-cell concentration response curves The optimal single channel rate constants determined from fitting the single channel data with the receptor model using QuB were transferred to
Techniques: Generated, Concentration Assay